Use this lipid calculator to estimate LDL-C from a standard lipid profile. ClinFuse defaults to mmol/L for South African labs, converts internally to mg/dL for the published Sampson equation, then reports LDL-C in mmol/L and mg/dL.
Calculated by the Sampson equation.
Total cholesterol minus HDL cholesterol.
Clinical decision support only. Verify unusual values, follow local guidelines, and interpret calculations alongside the full clinical picture.
Non-HDL Cholesterol = Total Cholesterol - HDL CholesterolLDL Cholesterol = (Total Cholesterol / 0.948) - (HDL Cholesterol / 0.971) - ((Triglycerides / 8.56) + (Triglycerides × Non-HDL Cholesterol / 2140) - (Triglycerides² / 16100)) - 9.44The published Sampson/NIH equation constants are mg/dL-based. ClinFuse uses the mg/dL formula and converts the result back to SI units after accepting mmol/L inputs by default.
The Sampson equation was developed and validated for triglyceride values up to 800 mg/dL, which is approximately 9.03 mmol/L. ClinFuse blocks calculated LDL-C output above that range and recommends direct LDL-C or specialist lipid interpretation.
Use this calculator as clinical decision support, not as a substitute for laboratory reporting or guideline-based cardiovascular risk assessment.
The equation was developed to improve calculated LDL-C accuracy, including in patients with higher triglycerides, compared with older calculated LDL-C equations.
These calculators are designed for clinician decision support and SEO-friendly public education. Verify results against the original method and the patient context before making decisions.